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We discuss the issue of the “Rosenthal effect” in moredetail in Chapter 6, but note it here because the threat of interactional and noninteractionalobserver bias is especially crucial for efficacy studies, where the desire to demonstratea treatment benefit is strong. The size of the insertionor deletion will determine whether the impact is to a singlegene, a series of linked genes, or a whole chromosome. (A) “Sunburst” calcifications on CT (A) are seen as a central scar pathologi-cally (B). (2002) A double-blind, placebo-con-trolled multicentre study of memantine in mild to moderate vascu-lar dementia (MMM500)

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