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Multiple copies of the connexin-26 gene were incorporated into the HeLa cell genome to achieveoverexpression ofthe connexin protein. A threshold dose is then projected from the LOAeL,usually by dividing the LOAeL by a factor of 10 (seeFigure 23.2). 1990 ),compared with preterm controls without BPD(Saigal and O’Brodovich 1987 ). It must be based on a careful assessment of fracture stability.
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